Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Valproic acid and ethosuxamide both trump lamotrigine when treating childhood absence epilepsy

Monotherapy with valproic acid or ethosuxamide is better than lamotrigine for treating childhood absence epilepsy, a US study reports (New England Journal of Medicine 2010;362:790).

With roughly 150 children randomised to each treatment, 58%, 53% and 29% of patients were free from treatment failure after 16 weeks with valproic acid, ethosuxamide and lamotrigine, respectively (P<0.001 for both valproic acid vs lamotrigine and ethosuxamide vs lamotrigine).

Attentional dysfunction, a secondary outcome, was more common with valproic acid than ethosuxamide (P=0.03).

Citation: Clinical Pharmacist URI: 11004596

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 1 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £138.50Buy now
  • BNF and BNF for Children

    BNF and BNF for Children

    Now available as a 2 year print subscription to both the BNF and BNFC, ensuring you have the latest medicines information as it publishes and at a greatly reduced price.

    £262.50Buy now
  • Further MCQs in Pharmacy Practice

    Further MCQs in Pharmacy Practice

    Further MCQs in Pharmacy Practice contains 600 practice-oriented pharmacy exam questions. Includes both open- and closed-book sections.

    £30.00Buy now
  • FASTtrack: Complementary and Alternative Medicine

    FASTtrack: Complementary and Alternative Medicine

    A quick-start guide to all the main types of Complementary and Alternative Medicine, providing both theoretical and practical information.

    £25.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.