Vitamin A analogues do not raise fracture risk
Large doses of systemic vitamin A analogues are not associated with an increased risk of fracture, a study has shown (Archives of Dermatology 2010;146:478).
The study of 124,655 patients with fractures and 373,962 control patients found no relationship between fracture risk and increasing dose of, or increasing duration of treatment with, vitamin A analogues.
Analysing vitamin A analogues isotretinoin and acitretin separately did not alter the findings.
Citation: Clinical Pharmacist URI: 11012806
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