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Extended stability for parenteral drugs, 5th edition (Book review)

By Laurence A. Goldberg

Looking at the quality standards of parenteral drugs

‘Extended stability for parenteral drugs, 5th edition’, by Caryn Dellamorte Bing and Anna Nowobilski-Vasilios. Pp xiv+326. Price $149. Maryland: American Society of Health-System Pharmacists; 2013. ISBN 978 1 58528 340 8

It is often difficult to find stability data for many parenteral drugs beyond 24 hours. This has been a complicating factor in the care of patients being treated at home. When home infusion practice emerged and grew in the 1980s–90s, accurate information on extended stability of compounded injections was limited. Pharmacists were challenged to find drug stability data that supported realistic and cost-effective compounding and delivery schedules to patients’ homes.

This book consists of 160 monographs. Each monograph represents a drug for which some extended stability information for the compounded injection is available. Practitioners who are unfamiliar with this book and the principles of extended stability should begin by reading the first chapter.

The monographs are presented in alphabetical order by generic name. Stability data for the drugs in various containers, solutions, concentrations, temperature, storage and administration conditions are included.

The list of monographs selected includes most of the anti-infective medicines and other parenteral drugs for which useful extended stability data are available. They cite the majority of extended stability data available at the time of publication. Many of the monographs are referenced by well known sources. Additional references and sources include previously unpublished data for specific types of infusion devices and containers, direct communications from drug and device manufacturers, and a focused review of previously published data from practitioners.

The practices and integrity of pharmacists who compound sterile preparations have been under great scrutiny recently, particularly in the US, in the wake of the New England Compounding Centre incident. Regulators, pharmacy boards and the public at large are aware of the issues and call on pharmacists to employ diligence and professionalism in this area of work. This book will assist in ensuring that the quality standards of compounded parenteral drugs are met. It will be a useful additional reference source to those healthcare professionals involved in the preparation or administration of ready-to-use or ready-to-administer parenteral drugs.

Laurence A. Goldberg is a pharmaceutical consultant from Bury, Lancashire

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2013.11120957

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