Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

PJ Online | News: Statin reduces gene-variant coronary risk

Home > PJ (current issue) > News / Daily News | Search

Return to PJ Online Home Page

The Pharmaceutical Journal
Vol 269 No 7226 p770
30 November 2002

This article

News summary

Related websites
American Heart Association (more)

Statin reduces gene-variant coronary risk

Carriers of a common variant in the gene encoding for the microsomal triglyceride transfer protein (MTP) have an increased risk of coronary heart disease (CHD), but this risk is reduced by statin therapy, researchers report.

Dr Helena Ledmyr, of the Karolinska Institute in Sweden, and colleagues from Glasgow and Oxford universities used data from the west of Scotland coronary prevention study (WOSCOPS) to investigate how MTP, which is involved in cholesterol metabolism, influences heart disease risk.

They showed that carriers of the variant (MTP-493T) had lower total cholesterol levels than carriers of MTP-493G and hypothesised that carriers of the T allele would have a reduced risk of CHD. However, what they actually found was that people with this genotype who were given placebo in the trial had increased risk of CHD. "This effect was completely eliminated in the pravastatin group," Dr Ledmyr said. She concluded that the increased risk of CHD seen in carriers of MTP-493T is unrelated to cholesterol and cholesterol risk factors, but eliminated by statin therapy.

The data were presented at the American Heart Association scientific sessions held in Chicago last week.

Back to Top

Home | Journals | News | Notice-board | Search | Jobs  Classifieds | Site Map | Contact us

©The Pharmaceutical Journal

Citation: The Pharmaceutical Journal URI: 20008298

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

RPS publications

Pharmaceutical Press is the publishing division of the Royal Pharmaceutical Society, and is a leading provider of authoritative pharmaceutical information used throughout the world.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Rate
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.