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PJ Online | PJ Letters: HRT

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The Pharmaceutical Journal
Vol 268 No 7195 p568-572
27 April 2002

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HRT

Link between vascular calcification and bone resorption

From Professor R. Corder, MRPharmS

I noted with interest your recent news item highlighting that hormone replacement therapy reduces arterial calcification (PJ, 13 April, p488). Although I have not read the paper you cited, I would like to bring to the attention of your readership the close link between vascular calcification and bone resorption.1 Indeed, the observations by Dr Julie Cox and colleagues of increased mammary vessel calcification in patients not receiving HRT may also be interpreted as indicating those patients who are suffering the greatest degree of osteoporosis.

Reference

1. Hofbauer LC, Schoppet M. Osteoprotegerin: a link between osteoporosis and arterial calcification? Lancet 2001;358:257?9.

Roger Corder
Professor of Experimental Therapeutics,
William Harvey Research Institute,
Barts and the London,
Queen Mary's School of Medicine and Dentistry, London EC1

 

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