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In this issue


3D model of PCSK9 molecule

Enthusiasm for PCSK9 inhibitors to lower LDL cholesterol is premature Subscription


Although PCSK9 inhibitors have been hailed as the next big thing in the treatment of high cholesterol, there are not enough data to make informed opinions about their overall value.


The effectiveness of granisetron transdermal patch in chemotherapy-induced nausea and vomitingSubscription


Chemotherapy-induced nausea and vomiting (CINV) is one of the most distressing side effects of chemotherapy. It can have a negative impact on quality of life and may discourage patients from continuing treatment. Economic impacts include costs of prolonged hospital stays, emergency admissions for dehydration, additional treatments, emotional support and depression. In severe cases, CINV could lead to serious complications and clinical decisions may be made to delay, reduce or stop chemotherapy.

Improving the use of medicines in East CheshireSubscription

By John Rushton, Laurelle Wilkinson, Hayley Bailey

East Cheshire’s Neighbourhood Integrated Medicines Optimisation (NIMO) team started as a small pharmacy project three years ago but, following clinical commissioning group financial support, a pharmacy service was developed and carved into this rural region.

Foods that cause blood glucose spikeSubscription


On the subject of obesity, there is some interesting work appearing. It relates to the body’s blood sugar response to various foods and also to the composition of one’s gut bacterial flora. For me, the blood glucose spike is the most interesting bit. What is clear is that blood glucose spikes that occur eating or drinking are a bad thing.

CPD article

Bipolar brain, 3D view of an MRI scan

Bipolar disorder: pharmacotherapy options with a focus on women of childbearing ageSubscription


Bipolar disorder and its implications for women of childbearing age, with a focus on the use of valproate and how this compares to other available pharmacologic treatments.

Micrograph of a blood filled micrograph

Bridging anticoagulation: perioperative management of patients on anticoagulantsSubscription


How patients on anticoagulants can be effectively managed in the perioperative period, including the evidence for the need for ‘bridging’ anticoagulation therapy and introduction of direct oral anticoagulants.

Perspective article

Close up of a man smoking an e-cigarette

E-cigarettes in smoking cessation: a harm reduction perspectiveSubscription

By , ,

Electronic cigarettes (e-cigarettes) are novel devices that simulate aspects of cigarette smoking and deliver nicotine to users. Evidence for their efficacy in smoking cessation, based on several randomised controlled trials of older devices, suggests a modest effect. They appear to be far less harmful than tobacco smoking, but the health effects of long-term use are unknown. Possible adverse population effects of widespread e-cigarette use, such as renormalising smoking ...

Clinical Pharmacist

CP April 2016, Vol 8, No 4

Cover Story:

E-cigarettes: a valid option for harm reduction

Read more…

Clinical Pharmacist

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Clinical Pharmacist is a monthly, peer-reviewed journal that provides authoritative resources on the clinical management of disease in relation to medicines and up-to-date information about advances in pharmacy and drug development. Clinical Pharmacist publishes Review articles, Perspectives, evidence-based CPD articles and Practice Reports on topics from drug discovery to clinical pharmacology and pharmacy.

The international audience of Pharmaceutical Journal Publications consists of pharmacists, pharmaceutical scientists and healthcare professionals. The journal is available to 44,000 members of the Royal Pharmaceutical Society, as well as non-member individual subscribers and subscribing institutions.