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Rapid review of treatments for novel coronavirus SARS CoV 2 infection

Investigational treatments for COVID-19

23 JUN 2020By , ,

A review of several of the treatments for COVID-19 currently being trialled.

Antibodies attacking cancer cell

Immuno-oncology agents for cancer therapySubscription

7 MAY 2020By ,

Abstract: Until recently, cancer therapy comprised of four main types of treatment: surgery, radiotherapy, chemotherapy and targeted therapy. Over the past decade, immuno-oncology (IO) has emerged as a novel and important approach to cancer treatment through the stimulation of the body’s own immune system to kill cancer cells. This newly recognised method of treating cancer is rapidly developing, with many accelerated approvals by the US Food and Drug Administration and European Medicines ...

Woman testing blood pressure

Effective detection and management of hypertension through community pharmacy in EnglandSubscription

17 MAR 2020By , , , , ,

Management of hypertension does not routinely occur in English pharmacies, despite community pharmacy being an ideal place for screening to take place. By examining and learning from the evidence, pharmacies in England can help patients maintain ideal blood pressure levels and improve health outcomes.

Blood samples

The precision medicine approach to cancer therapy: part 2 — haematological malignanciesSubscription

28 FEB 2020By , , , ,

An overview of the anticancer agents that have been approved for use in the UK as part of a precision medicine approach for haematological malignancies, along with information relating to the relevant biomarkers and biomarker assays currently available. 

SEM of intestinal microvilli

Recent advances in the oral delivery of biologicsSubscription

10 JAN 2020By ,

An overview of the key physiological barriers to oral delivery of biologics and the strategies to overcome them that are currently being tested.

Polymerase chain reaction machine

The precision medicine approach to cancer therapy: part 1 — solid tumoursSubscription

8 NOV 2019By , , , , ,

An overview of the anticancer agents that have been approved for use in the UK as part of a precision medicine approach for solid tumours, along with information relating to the relevant biomarkers and biomarker assays currently available.

patient with inhaler for COPD

Role of dual and triple fixed-dose combination inhalers in the treatment of chronic obstructive pulmonary diseaseSubscription

5 NOV 2018By ,

A review of the current evidence, including the safety and efficacy of dual and triple-combination inhalers for the treatment of stable COPD, and their place in therapy.

Acute care and resuscitation training. Medical staff undergoing training using a mannequin.

Simulation-based training: applications in clinical pharmacySubscription

4 SEP 2018By , ,

With the evolving role of pharmacists and the growing complexity of healthcare, there is a need for interventions and innovations to enhance both individual task and team performance. Simulation-based training is an educational platform with potential in this area. This article outlines its applications in pharmacy and how it can support the skill acquisition and development of pharmacists.

Drug user injecting heroin in foot

Risk factors for mortality, hospitalisation and imprisonment in substance misuse patientsSubscription

6 JUL 2018By , ,

Pharmacists should be aware of the mortality rates and adverse outcomes, including hospitalisation and imprisonment, that are rife in illicit drug users and patients on opioid substitution therapy, in order to optimise patient safety and reduce adverse outcomes.

Antibiotic testing, antimicrobial resistance (AMR), agar dish

Pharmacy’s role in antimicrobial resistance and stewardshipSubscription

5 JUN 2018By , , Rachel Joynes,

This article summarises the evidence supporting the role of pharmacists and pharmacy teams in antimicrobial stewardship and outlines the impact of their activities.

Leaflets pharmacy services

Community pharmacists' contribution to public health: assessing the global evidence baseSubscription

6 APR 2018By , , ,

In the UK, community pharmacies are more accessible to the general population than general practices. Therefore, government white papers and briefing documents from pharmacy professional bodies have advocated the expansion of the role of community pharmacists, particularly in relation to the provision of services that contribute to disease prevention and health improvement. It is unknown whether the same evidence exists globally for the expansion of these roles. This article attempts ...

Heart stress test and diabetes test

Glucose-lowering drugs and cardiovascular risk: how recent outcome trials have informed practiceSubscription

4 APR 2018By ,

Although large clinical trials with glucose-lowering drugs have consistently shown beneficial reductions in microvascular complications, their effects on macrovascular complications have been controversial. Interpreting these trials is complicated by substantial differences in their design, the populations studied and data analysis. This article examines how the trials have evolved and how they impact the use of glucose-lowering agents in the routine care of patients with type ...

Micrograph of T-cell infected with HIV viruses

Optimising the health and wellbeing of older people living with HIV in the United Kingdom Subscription

7 FEB 2018By

Care for people with HIV has improved, meaning that more people are living with HIV into older age with normal life expectancy. Therefore, there are various challenges and opportunities facing healthcare professionals when providing care to this changing demographic.

Illustration showing the path of pain and its inhibition at the level of the neurons of the spinal cord

Treatments for neuropathic painSubscription

Clinical Pharmacist, December 2017, Vol 9, No 12By ,

Neuropathic pain is a common condition characterised by subjective negative and positive symptoms that range from numbness to debilitating pain.

Abstract illustration of pain - naked man standing against red background

Pharmacological treatment options for fibromyalgiaSubscription

7 NOV 2017By , ,

Fibromyalgia is a high-impact and prevalent condition. Its clinical features include widespread pain and tenderness — often associated with high levels of poor-quality sleep, fatigue and cognitive dysfunction. The mechanism leading to fibromyalgia development is associated with a change in the sensitivity of the pain-related nervous system, as well as other sensory systems. In turn, emotional distress plays a facilitatory role in this process. Non-pharmacological management focuses ...

13-year-old girl with autism hiding her face in her hands

Pharmacologic treatment options for children and adolescents with autism spectrum disorderSubscription

10 OCT 2017By , , , , ,

Autism spectrum disorder (ASD) is a heterogeneous neuropsychiatric condition that is often associated with severe behavioural challenges that can be as diverse in response to treatment as they are in presentation. While environmental, behavioural, communicative, therapeutic and supportive interventions are critical considerations for any individual with ASD, pharmacologic interventions are often helpful and can be necessary for improving level of functioning and quality ...

Scanning electron micrograph of methicillin-resistant Staphylococcus aureus (MRSA) bacteria

Antimicrobial therapies for Gram-positive infectionsSubscription

12 SEP 2017By , , ,

Gram-positive bacteria are among the most common human pathogens associated with clinical infections, which range from mild skin infections to sepsis. In an era defined by antimicrobial resistance (AMR) and an increasing drive toward delivering patient care via ambulatory pathways, the paradigm for the management of infections is changing. Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), the best known cases of ...

Transmission Electron Micrograph view (TEM) of Hepatitis B virus

An update on the management of chronic hepatitis B and C infectionSubscription

9 AUG 2017By , , , ,

Chronic hepatitis B and C infection are leading causes of liver-related morbidity and mortality worldwide. Current therapies for chronic hepatitis B virus (HBV) infection consisting of nucleos(t)ide analogues (NA) rarely lead to functional cure. With a better understanding of the HBV lifecycle, novel agents have been developed with the hope of achieving functional cure. The development of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) therapy has led to ...

Pharmacist preparing prescriptions at a dispensary

Safe dispensing in community pharmacies: applying the software, hardware, environment and liveware (SHELL) modelSubscription

Clinical Pharmacist, July 2017, Vol 9, No 7By , , , ,

The human aspects of the community pharmacy work system are vulnerable to medication-related errors. Established models of human error can identify actual or potential hazards, and are important in our understanding of the interaction between human and system factors that influence performance. The software, hardware, environment and liveware (SHELL) model, a traditional human factors framework, is used in this article to classify potential sources of error in community ...

Telepharmacy, pharmacist in front of computer screen

Examining the implications of analytical and remote monitoring in pharmacy practiceSubscription

5 JUN 2017By , ,

Remote patient monitoring (RPM) incorporates digital technology that collects health data from individuals in one location and electronically transmits secure data to healthcare providers in a different location for review and assessment. This allows healthcare professionals to make recommendations to optimise patient care without the patient having to be in the healthcare setting. With the implementation of RPM, pharmacists can use objective data obtained by remote ...

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