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Plasmacytoid urothelial carcinoma

US FDA approves first PD-1/PD-L1 inhibitor for most common bladder cancerSubscription

The US Food and Drug Administration has approved the immunotherapy atezolizumab (Tecentriq) to treat urothelial carcinoma, the most common form of bladder cancer.

Medicines and healthcare Products Regulatory Agency offices in central London

Drug wholesalers vent concerns about government’s hub and spoke plansSubscription

A trade body representing drug wholesalers who distribute more than 92% of NHS medicines has warned that the full implications of hub and spoke technology have yet to be determined and its widescale implementation risks reducing the quality and safety of dispensing.

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Ultrasound of baby during the first trimester

Pregabalin linked to major birth defectsSubscription

Exposure to pregabalin during pregnancy associated with three-fold increase of non-chromosomal birth defects.

US prescription bottles

Drug switching could save US health system billionsSubscription

Drug classes with the highest excess expenditure in the United States are statins, atypical antipsychotics and proton pump inhibitors, study finds.

Illustration of intestinal villi and gut micro biomes

Narrow spectrum antibiotic leaves gut microbiome intact in miceSubscription

Pathogen-selective antibiotics could minimise the impact of treatment on the gut microbiome, study finds.

Digitally coloured transmission electron micrograph showing a single human immunodeficiency virus (HIV)

New target for HIV vaccine foundSubscription

The fusion peptide is a new region of interest for HIV vaccine development, researchers say.

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View of different open booths where users can inject their drugs

Making the case for drug consumption roomsSubscription

For the past 15 years, drug users living in Sydney, Australia, have had access to a safe place to inject their drugs, supervised by trained medical staff. Is it time for other cities to follow suit?

Illustration of research and multiple sclerosis showing scientists, brain with multiple sclerosis and a demyelinated sheath of a nerve fibre

Search for progressive multiple sclerosis treatment is gathering momentumSubscription

There are currently no effective treatments to slow or stop progressive multiple sclerosis (PMS) but recent advances in understanding the complex pathogenesis of the disease, as well as efforts to improve outcome measures, identify biomarkers and refine clinical trial design, mean progress is speeding up.

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Infographic showing the drug targets in rheumatoid arthritis

Blocking the immune system in rheumatoid arthritisSubscription

Rheumatoid arthritis is caused by the immune system attacking the body. It afflicts about 1% of people in the UK and is now treated with a variety of biologic drugs that dampen the immune system in different ways

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Special report

Mental Health Awareness

Among people under the age of 65 years, nearly half of all ill health relates to mental illness but only a quarter of all those with mental illnesses such as depression are in treatment. Here, you can find news stories and articles on topics ranging from antidepressant use during breastfeeding to the use of antipsychotics in care homes.

Image: Self Portrait 15, painted 27th June 1991 from The Self Portrait Series by Bryan Charnley. © James Charnley and SANE (www.BryanCharnley.info). Described by the artist as: "An extremely complicated picture as I feel I am closing in on the essential image of my schizophrenia."

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A reference you need

Introduction to Pharmaceutical Calculations

Together with its companion text Pharmaceutical Calculations Workbook, Introduction to Pharmaceutical Calculations is essential reading for pharmacy undergraduates and pre-registration pharmacists.

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