PD-1 and PD-L1 inhibitors induce a higher response rate across a wider range of tumours than other immunotherapies.
Ulf Wiinberg has resigned as chief executive of the Danish pharmaceutical company Lundbeck after breaching the company’s code of ethics.
The European Medicines Agency has amended its policy on handling declarations of interest to ensure pharmaceutical experts are not unduly excluded.
Methods to improve patients’ adherence to medicines are generally unproven and there is an urgent need to develop more effective approaches, say researchers.
EllaOne to be available without prescriptionSubscription
EllaOne (ulipristal acetate), an emergency contraceptive, is to be made available without a prescription from community pharmacies throughout the European Union.
The European Union (EU) and the United States have criticised Russia’s move away from open trade and introduction of policies that discriminate against foreign imports, including pharmaceuticals and medical devices.
Hospital employees who work with patients wash their hands less frequently as they get deeper into their shifts, a study finds.
A fast-track approach is needed over the next five years for the AIDS epidemic to cease to be a global health threat by 2030, according to a report by UNAIDS released on 18 November 2014.
The cognitive performance of elderly participants involved in a two-year study did not benefit from vitamin B12 and folic acid supplements.
The World Health Organization has issued an official statement to encourage pharmaceutical companies to publicly disclose clinical trial results.
The benefits of using domperidone to increase milk supply in breastfeeding mothers outweigh its risks, argues a researcher at the University of Adelaide, South Australia.
Move to scrap the role of chief scientific adviser has been described as ‘deeply disappointing’.
Increasing bacterial resistance across Europe, particularly to carbapenems and polymixin antibiotics, is a “threat to public safety”.
Half of teenagers and young adults with kidney disease have used smartphones to help them remember to take their medicines, a study suggests.
Ebola research projects receive £1.34mSubscription
A hand-held device to test bodily fluids for the Ebola virus is among five new research projects announced by the UK government and the Wellcome Trust.
Case of bird flu confirmed in UKSubscription
A case of avian influenza has been confirmed in the UK by the Department for Environment, Food and Rural Affairs.
Guido Rasi, the executive director of the European Medicines Agency (EMA), has been forced to step down after a “procedural error” in the process that appointed him to the position.
The World Health Organization has issued new guidelines to expand access to naloxone in an effort to reduce the number of deaths caused by overdoses of opioids.
GlaxoSmithKline and Bayer outperform Roche and Johnson & Johnson in corporate transparency studySubscription
Many of the world’s 124 largest publicly listed companies disclose little or no financial details about their operations outside their parent country.
Research suggests that dabigatran is associated with a higher risk of bleeding compared with warfarin in a US population sample.
A fatal case of progressive multifocal leukoencephalopathy has been reported for the first time in a patient receiving dimethyl fumarate (Tecfidera).
An enzyme that kills meticillin-resistant Staphylococcus aureus (MRSA) has been developed by Dutch biotech company Micreos.
Researchers have identified an agent that interferes with the cell signalling protein KRAS and which produces a dose-dependent reduction in tumour growth in a mouse model.
Point-of-care testing for a biomarker of bacterial infection would help to limit unnecessary antibiotic prescribing by GPs, suggests a systematic review.
The latest report from the Intergovernmental Panel on Climate Change (IPCC) confirms — with 95% certainty — that human influence on the climate is growing.
Patients recently diagnosed with diabetes who are prescribed metformin monotherapy are less likely to require treatment intensification compared with patients prescribed other oral glucose-lowering medications as a monotherapy.
A study finds 94% of participants wrongly believed they were allergic to penicillin.
The European Union has pledged 280m euro to a research project to develop vaccines and diagnostic tests for Ebola.
Relatives of a woman who died after a dispensing error are to take civil action, the family’s lawyers have confirmed.
‘Inflated’ prices set by drug companies for breast cancer treatments are creating a barrier that no regulatory system can overcome, a cancer charity argues.
The number of medicines use reviews and new medicine service interventions has risen steadily in England’s community pharmacies.
NHS England issues naloxone warningSubscription
Inappropriate use of naloxone can cause patients severe distress and can be fatal, says NHS England in a Patient Safety Alert.
NHS staff in Wales on ‘Agenda for change’ pay scales will receive a 1% consolidated pay rise from April 2015 in a deal agreed between unions and the Welsh government.
Government-backed plan supports greater role for pharmacy in management of high blood pressureSubscription
Community pharmacists should be commissioned to provide services that improve the management of people with high blood pressure or those who are at risk.
GPhC reviews fitness-to-practise guidelinesSubscription
Pharmacists who are dishonest with patients when care goes wrong could be removed from the professional register, the General Pharmaceutical Council has proposed.
Plans may include integrating the health service with life sciences research to bring innovations to patients faster.
What has been happening in the world of pharmacy? Here’s our pick of must-read news from the past month…
NHS expenditure on prescribed medicines up by 7.6%, with 15.1% increase in hospital sectorSubscription
The cost of medicines prescribed by hospitals in England increased by 15.1% to £5.8bn in 2013–2014 compared with the previous year.
All patients in England will be able to access their own GP records by March 2015 and their entire healthcare records by 2017, under plans contained in a report by the National Information Board.
The UK Government is to inject an extra £300m into the NHS to help support local health services as winter approaches.
Cancer charities and the pharmaceutical industry have expressed concerns over the way cancer medicines are appraised after a revised process for assessing drugs available through the Cancer Drugs Fund was published by NHS England.
Lloydspharmacy funds pilot project to improve care of patients after discharge from hospitalSubscription
Lloydspharmacy stores in Liverpool are set to pilot a new model of community pharmacy-based discharge care, as a result of a new research collaboration.
It is the first time researchers have put a figure on the prevalence of inpatients who are smokers in hospitals in England.
Government drug advisers have rejected a proposal by government ministers to impose a time limit on prescribing methadone to heroin addicts.
Wales will not have a Cancer Drugs Fund, despite a 98,000-signature petition calling for equity of access to cancer drugs for patients in England and Wales being handed to the Welsh Assembly on 5 November 2014.
A bill going through Parliament wants the National Institute for Health and Care Excellence (NICE) to appraise off-patent drugs to allow them to be used for new indications.
Pharmacy COPD-screening could save the NHS £264mSubscription
Community pharmacies can help identify undiagnosed cases of chronic obstructive pulmonary disease at an early stage, which could result in savings of around £264m per year, a pilot study suggests.
Pharmacists and clinical pharmacologists to collaborate following call for more consultant postsSubscription
Pharmacists and clinical pharmacologists are to look at how they can work together to improve patient care and increase the potential of medicines management to save NHS funds.
Around £2bn of savings could be made in the NHS through reducing waste and improving clinical practice, says a report by the Academy of Medical Royal Colleges.
Resistance to antibiotics used to treat gonorrhoea is increasing in England and Wales, according to figures published in the 2013 Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) report.
Pharmacists are likely to be dealt with fairly if they find themselves up before the professional regulator’s fitness-to-practise committee, according to published research.
Doctors have been instructed to prescribe antivirals for patients with severe influenza and not to be swayed by data showing that these drugs may not be effective.
NHS must commit to national targets to use fewer antibiotics to halt the rise in antimicrobial resistance, according to a coalition of health professional bodies.
All pharmacists, even UK nationals, will in future have to be competent in speaking English if they want to practise in the UK, under new proposals.
New research suggests that selective cyclooxygenase-2 inhibitors herald worse outcomes following ischaemic stroke.
Hopes for a vaccine to tackle glioblastoma are bolstered by positive results from a phase I trial reported in Cancer Immunology and Immunotherapy.
Research findings support a role for memantine as a potential pharmacological treatment for binge-eating disorder.
Researchers have used “test-negative design” case-control studies to assess the effectiveness of seasonal influenza vaccine.
Androgen deprivation therapy increases cardiac mortality for men with heart failure or a prior myocardial infarction, research shows.
Researchers have used micro-costing to discover the cost of a medication review service in a care home given by a multidisciplinary team.
Eribulin improves overall survival in women with advanced breast cancer, with the greatest benefit seen in women with triple-negative disease, new research suggests.
mTOR inhibitor suppresses tumour formationSubscription
Research suggests a new approach to cancer prevention in people predisposed to colorectal cancer because of the inactivation of the adenomatous polyposis coli (Apc) gene.