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For the first time, a new drug is being developed to work by modulating the activity of the microbiome, the 100 trillion bacteria that inhabit the human gut. The image is a scanned electron micrograph of the intestinal villi where microbiomes are found

Drug metabolism: manipulating the microbiome Subscription

Understanding how symbiotic bacteria that help maintain health interact with medicines is an emerging field of research.

Rain pouring down on Mt Hood National Forest in Oregon, USA

The secret life of ketamineSubscription

Ketamine is being used to treat depression in clinics that are springing up across the United States, but uncertainty remains over its long-term use.

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Complete the CPD modules and receive your certificate from The Pharmaceutical Journal.

Coloured 3D computed tomography (CT) scan of the abdomen of a patient with impacted bowels, which could occur in patients with untreated constipation

Constipation: managing the condition in adultsSubscription

How to assess patients with constipation and select the right treatment to minimise the risk of complications.

Dialysis involves passing the patient’s blood against a semi-permeable membrane. The main options are haemodialysis (HD) pictured, using a dialysis machine and peritoneal dialysis (PD), which uses the patient’s peritoneum

Dialysis: principles and treatment optionsSubscription

How to choose between haemodialysis and peritoneal dialysis when starting renal replacement therapy.

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Linaclotide, lubiprostone and prucalopride interactionsSubscription

How to avoid potential pharmacokinetic and pharmacodynamic interactions with the latest medicines for managing constipation.

In the image, a colour x-ray of a coronary artery with Kawasaki disease, a type of vasculitis. Vasculitis is a collection of rare diseases characterised by the inflammation of blood vessel walls.

Managing ANCA-associated vasculitisSubscription

Treatment of vasculitis associated with antineutrophil cytoplasmic antibodies requires immunosuppressive therapies and close monitoring of the patient to manage toxicity.

X-ray of deep vein thrombosis, pictured. Low molecular weight heparins (LMWHs) are used widely for the prophylaxis and treatment of venous thromboembolism (VTE).

Low molecular weight heparins for treating venous thromboembolismSubscription

How to start patients on these common injected anticoagulants and optimise treatment.

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‘Selling your pharmacy for all it’s worth’ by Anne Hutchings

Useful tips and advice on how to sell your pharmacySubscription

By Brian Deal

‘Selling your pharmacy for all it’s worth’ by Anne Hutchings.

‘Rules and guidance for pharmaceutical distributors 2015’

Preparation for regulatory inspectionsSubscription

By

‘Rules and guidance for pharmaceutical distributors 2015’.

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Industry pharmacist Zahid Latif (pictured) is responsible for managing a £100m portfolio of investments supporting pioneering medical and health projects in the UK

Promoting medical innovation as a pharmaceutical scientistSubscription

Zahid Latif has worked in drug discovery projects across the UK and now leads efforts to promote innovative medical research collaborations between industry and academia.

From July 2014, all employees with 26 weeks’ continuous employment are now able to submit a flexible working request

How changes to UK flexible working laws affect pharmacistsSubscription

Kevin McKenna, head of employment law at Kuits Solicitors in Manchester, explains how changes to laws on flexible working have affected employers and employees.

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David Branford is the English Pharmacy Board chair

RPS chair: GP practice role will help develop clinical future for the professionSubscription

Creating opportunities in general practice for pharmacists will allow to the profession to adopt a greater clinical role in care, says the English Pharmacy Board chair David Branford.

Bruce Warner, deputy chief pharmaceutical officer, said “the time is right” for more pharmacists to work as part of GP practice teams across the country

NHS England calls for assessment of pharmacists' skills for GP practice roleSubscription

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Deputy chief pharmaceutical officer warns NHS not to introduce pharmacists in GP surgeries initiative in a “reckless” manner, and says skills and training requirements must be assessed first.

Your RPS

NHS funding provided to GPs for them to deliver travel health services to their patients could be shifted to community pharmacy, according to a travel health expert

GP travel health funding could shift to pharmacySubscription

NHS funding provided to GPs for them to deliver travel health services to their patients could be shifted to community pharmacy, according to a travel health expert.

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EMA fast tracks approval of thyroid cancer drugSubscription

The European Medicines Agency is recommending that Lenvima (lenvatinib) be available across Europe for the treatment of some patients with thyroid cancer.

Patients with late-stage terminal illnesses can often safely stop taking statins, and may even benefit from discontinuing them, according to new research

Patients can stop taking statins in terminal care, research suggestsSubscription

Discontinuing statin use in patients with late-stage terminal illnesses is safe and may even be beneficial, according to research in JAMA Internal Medicine.

HPV vaccine Gardasil 9 is approved by European drug regulatorSubscription

A human papillomavirus vaccine that protects against nine different strains of the virus has been given preliminary approval by the European Medicines Agency.

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Superdrug (pictured) has become the first retailer in the world to sell the personal DNA testing kit 23andMe in its stores. The DNA testing kit has been banned in the United States

Superdrug is first retailer in the world to sell DNA testing kit in storeSubscription

Superdrug has become the first retailer in the world to sell the 23andMe DNA testing kit in its stores, with the product positioned to reach as many customers as possible.

UK to become first country to offer meningococcal B vaccine to babiesSubscription

The meningococcal B (MenB) vaccine is to be added to the UK’s national childhood immunisation programme, likely from September 2015.

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Chinese researchers have developed a recombinant adenovirus type-5 vector-based Ebola vaccine that expresses the envelope glycoprotein from the 2014 epidemic strain. In the image, a scanned electron micrograph of the Ebola virus

Ebola vaccine based on 2014 virus strain is safe, trial showsSubscription

Chinese researchers have developed a recombinant adenovirus type-5 vector-based Ebola vaccine shown to be safe and “robustly immunogenic” in a phase I study.

Researchers have developed polymeric nanoparticles loaded with the antibiotic clarithromycin which were able to reach Staphylococcus aureus (pictured) located inside individual lung cells, without toxic effects

Researchers use nanoparticles to deliver antibiotic to lung cellsSubscription

Nanoparticles containing the antibiotic clarithromycin are able to reach Staphylococcus aureus located either in biofilms or inside individual lung cells, find researchers

Results from a phase 2 trial involving mongersen (GED-0301), an oral SMAD7 antisense oligonucleotide shows promise against Crohn's disease. In the image, an x-ray of a patient with Crohn's disease

Crohn’s disease investigational drug shows promise, phase II trial showsSubscription

Mongersen, an investigational agent being developed by Celgene, has been tested in Crohn’s disease and researchers have seen clinical remission in some patients.

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A pharmacist's journey through the Ebola epidemic

Pharmacist Claire Liew is currently volunteering at an Ebola treatment centre in Sierra Leone. She explains how the disease has affected everyday life.

How do you feel after you’ve made an error?

Healthcare professionals can feel traumatised when they make an error. Patsy Edwards describes research she conducted into the emotional impact of errors on practitioners and the support they subsequently received.

Contain eating to a 12-hour window to contain weight

Pamela Mason describes research that suggests eating in a confined window of time may help to reduce weight gain.

Could a probiotic pill cure diabetes?

Recent news stories have suggested that a new probiotic pill could cure both type 1 and type 2 diabetes. However, much more research is required before these claims can be substantiated, writes Pamela Mason.

Annoying noises and sound sensitivity

People with misophonia experience negative emotions when they hear specific sounds. Separately, phonophobia is the fear of loud sounds.

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Promotional feature

Visit the PROTECT website at www.protect-cpd.com for a free CPD-accredited, in-depth and interactive, e-learning programme on advanced pharmacy management of acid reflux

Step into the limelight – pharmacists to take the lead in advancing the management of acid reflux

So, step into the limelight!  In this article we review the current thinking in the management of heartburn and acid reflux in community pharmacies, and provide guidance and practical tools for the entire pharmacy team to support a customer-centric approach to care.

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Smoking cessation remuneration needs to improveSubscription

According to research by University College London (The Pharmaceutical Journal 2015;294:293), the drop in the number of smokers who quit smoking through the NHS Stop Smoking Service was mainly a result of insufficient investment in advertisement for the service. I believe the decline is also caused by the low remuneration ...

Unintended consequences of pharmacists working in GP practicesSubscription

I was most agreeably surprised when watching ‘Breakfast’ on BBC to learn that the Royal College of General Practitioners is recommending that every GP practice should have its own pharmacist. Also it was good to see the interview with a pharmacist working in such a practice. From what the pharmacist was saying, it would seem to be ideal for all parties with the pharmacist managing many long-term patients. He also suggested that such arrangements would mop up the current surplus of pharmacists. H

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Reader's comment

NHS England have had 2 years to undertake an impact assessment, so there's small chance of them doing it over the next 2 weeks remaining. Central NHSE support for the various Area Teams, who have inherited LPS since they are not national contracts, has been conspicuous in its absence. As a result, the ATs themselves seem to be winging it as best they can, and existing LPS contractors are actually doing the research work NHSE should have done, as part of their new contract proposals.

Nick Ford RPS warns NHS England over withdrawal of funding for small pharmacies