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Toe amputee

MHRA updates canagliflozin lower limb amputation warning

The Medicines and Healthcare products Regulatory Agency (MHRA), which regulates drugs and devices in the UK, has updated its advice concerning the increased risk of lower limb amputation associated with canaglifozin, a drug used to treat type 2 diabetes.

different classes of drugs - polypharmacy

Drug classes commonly implicated in causing kidney injury identified

Researchers have identified the drug classes that are frequently implicated in causing acute kidney injury after analysing adverse drug reactions in a French national pharmacovigilance database.

Female patient using an inhaler

Study identifies most important inhaler technique errors that are linked to poor asthma outcomes

A study of 3,660 patients across eight countries has identified the types of inhaler technique errors that are associated with the greatest impact on asthma outcomes.

The degradation of a low-density lipoprotein molecule (LDL, upper right), LDL receptor (orange, centre-left) and a molecule of the enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9, blue)

PCSK9 inhibitor evolocumab cuts risk of cardiovascular events, study results show

New mantra should be to get cholesterol as low as possible, researchers conclude.

Rivaroxaban, marketed by Xarelto

Rivaroxaban more effective than aspirin for preventing blood clots, study results suggest

Researchers find that blood clot rates in patients taking rivaroxaban were significantly lower than those taking aspirin, and there were no significant differences between bleeding side effects.

Jeremy hunt, secretary of state for health

Government lawyers defend community pharmacy budget cuts in High Court

Lawyers representing health secretary Jeremy Hunt have defended his decision to slice more than £320m off the community pharmacy budget in England.

Close up of cream labels that include paraffin

BBC investigation prompts reminder on fire risk warning for skin creams

Healthcare professionals have been reminded of the fire risk associated with paraffin-containing skin creams, following a BBC radio programme that highlighted the potential dangers.

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High Court, London

NPA argues its case against community pharmacy cuts in High Court

The National Pharmacy Association, a trade association representing independent pharmacy owners, has added its weight to the legal attack on government plans to slash £320m off the community pharmacy budget. 

Vaughan Gething, health secretary in Wales

Reforms to Individual Patient Funding Request system in Wales approved

Patients in Wales will no longer have to prove they have “exceptional clinical circumstances” in order to access drugs that are not routinely available on the NHS.

The Royal The Courts of Justice in London, which house the High Court and Court of Appeal of England and Wales

High Court told community pharmacy cuts introduced without 'basic fairness'

The impact of the government slashing more than £320m from the community pharmacy budget in England was spelt out to a High Court judge on 21 March 2017 as the legal challenge to the cuts began.

Sue Sharpe, chief executive of the PSNC

PSNC and NPA prepare to challenge government in court over community pharmacy funding decisions

The legal challenges to the government’s decision to cut the community pharmacy budget in England — first announced in December 2015 — are due to begin in the High Court on 21 March 2017.

Ian Crompton, head of healthcare banking services at Lloyds Bank Commercial Banking Group

Business confidence among pharmacists hits rock bottom, Lloyds bank index reveals

Business confidence among community pharmacists in England has fallen to a record low, according to the results of the annual Lloyds Bank Commercial Banking Healthcare Confidence Index.

NHS walk-in sexual health centre, Liverpool city centre

Financial pressures are harming community-based NHS services, King's Fund report says

Financial pressures on the NHS are harming community-based services, while some acute services are being shielded from cuts, putting the NHS ‘Five year forward view’ at risk, according to an analysis by The King’s Fund.

General Pharmaceutical Council signage

Pharmacy regulator appoints financial services expert as deputy chief executive

The General Pharmaceutical Council (GPhC) has appointed Megan Forbes as its deputy chief executive and director of operations, effective from 5 June 2017.

All United Kingdom

Sad child facing wall

ADHD treatment well-tolerated in paediatric anxietySubscription

Researchers found small decreases in blood pressure and heart rate in patients treated with guanfacine, and say further clinical testing is needed.

Molecular structure of fentanyl

Researchers create opioid that only activates at pain sitesSubscription

Opioid-receptor agonist demonstrated similar level of pain relief to fentanyl but without typical side effects associated with opioids.

Smoker lighting a cigarette

Brain activity predicts success of attempts to quit smokingSubscription

Researchers found that smokers who relapsed while trying to quit had a reduced functional connectivity between brain regions involved in inhibitory control, compared to those who remained abstinent.

Blister pack of pravastatin

No survival benefit from adding statins to lung cancer treatmentSubscription

Adding pravastatin to platinum-based chemotherapy offered no benefit to survival compared with placebo, researchers report.

Ovarian cancer cells

Researchers discover molecule that inhibits cancer cell stress responseSubscription

Scientists find a new chemical probe that is a potent inhibitor of human cancer cell proliferation in vitro, with potential applications against many cancers.

Molecular structure of ketamine

Antidepressant response associated with increased resilience to stress in miceSubscription

Researchers say their study using a mouse model of chronic social defeat stress could be applied to identify novel drug targets for depression therapies.

Micrograph of Staphylococcus aureus bacteria (yellow) on human nasal epithelial cells

Salicylic acid exposure might increase risk of Staphylococcus aureusSubscription

Animal research suggests that frequent consumption of aspirin could contribute to S. aureus infection.

Micrograph of the Zika virus

Zika candidate vaccine confers durable protection in animal trialsSubscription

Researchers found that a single dose of their mRNA-based Zika vaccine could protect mice for up to five months.

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Special report

Community pharmacy cuts

On 21 March, the UK High Court will consider two legal actions against the government’s decision to cut community pharmacy funding. The joint hearing will consider cases put forward by the Pharmaceutical Services Negotiating Committee (PSNC) and the National Pharmacy Association (NPA). Follow the judicial review with The Pharmaceutical Journal’s special report on community pharmacy cuts.

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