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Close up of older woman with hearing aid

Increased duration of OTC painkiller use increases risk of hearing loss

Researchers say their findings suggest that a “significant proportion” of hearing loss is owed to paracetamol or NSAID-related ototoxicity.

Child's ear

Data lacking on childhood hearing loss following platinum-based cancer therapySubscription

Inconclusive data review leads researchers to advise clinicians to continue warning patients about the risk of hearing loss resulting from platinum-based cancer treatment.

Lumbar puncture being performed on a newborn baby

Targeted treatment shows promise for severe spinal muscular atrophySubscription

Antisense drug nusinersen was well tolerated in trial of 20 babies with SMA, with majority showing improved muscle skills and function after treatment.

GP takes blood pressure of patient

Ambulatory blood pressure higher than clinic BP, study showsSubscription

Researchers say 24-hour ambulatory BP monitoring could benefit people with prehypertension following trial of 888 people. 

Older patient using a frame

Pharmacist review boosts detection of inappropriate prescribingSubscription

Inclusion of a pharmacist in the multidisciplinary team could detect more cases of potentially inappropriate prescribing, study results suggest.

Feet of newborn baby

Vitamin D levels at birth linked to MS risk in later lifeSubscription

Researchers found an inverse relationship between vitamin D levels in dried blood spots up to seven days after birth and the risk of developing MS in later life. 

MRI showing intracerebral haemorrhage

Proton pump inhibitors may increase risk of first stroke Subscription

Data from 244,679 patients that had undergone endoscopy show that stroke incidence was 19% higher in patients who filed a prescription for a PPI compared with those with no PPI exposure

Mammogram breast scan image

Heart failure drugs might reduce Herceptin cardiac riskSubscription

Researchers say perindopril or bisoprolol may increase patients’ chance of receiving full course of trastuzumab, which is often stopped at the first sign of heart failure. 

Ultrasound image of a fetus in the womb

Propensity for depression programmed during fetal developmentSubscription

Patients with no CYP2C19 enzyme expression in the womb had a lower prevalence of depressive disorder compared with those who expressed the enzyme, researchers found. 

Micrograph of the section of a coronary artery with atherosclerosis and thrombosis

PCSK9 inhibitor shows plaque reduction benefitSubscription

Patients with coronary disease who were treated with evolocumab achieved lower LDL-C levels and greater plaque reduction, trial results show.

Micrograph of Shigella bacteria

Predatory bacterium could fight drug-resistant superbugsSubscription

Using Bdellovibrio to control Shigella infection in zebrafish larvae, researchers say this type of living antibiotic could hold potential for tackling antimicrobial resistance.

Close up of statin pills

Statins effective at preventing first heart attack or strokeSubscription

Statins were associated with a 36% lower risk of heart attack and 29% lower risk of stroke compared with placebo in a review of data from more than 70,000 patients.

Micrograph of an HIV virus budding out of an infected T-lymphocyte cell

Immune stimulation could boost therapeutic HIV vaccineSubscription

Combining HIV vaccination with immune stimulation delayed viral rebound in monkeys with simian immunotherapy virus.

Newborn baby's feet

Dextrose gel prevents hypoglycaemia in newbornsSubscription

Study results show that newborns given dextrose gel were less likely to develop hypoglycaemia, but researchers say more research is required in babies from other risk groups.

Pregnant woman holds a blister pack of pills

Exposure to SSRIs during pregnancy increases offspring’s risk of speech disordersSubscription

Study results show that children born to mothers who took SSRIs during pregnancy were more than a third more likely to have speech/language disorders.

Molecular structure of trimethoprim

New Zealand pharmacists support OTC trimethoprim prescribingSubscription

Pharmacists in New Zealand who are allowed to give women with uncomplicated cystitis a three-day supply of trimethoprim say patients appreciate the improved access to treatment.

Open pill bottle with different medicines spilling out

Fixed dose combination products have little impact on medicines adherenceSubscription

While persistence rates favoured patients taking a fixed dose combination of a statin and ezetimibe, it made no difference to adherence, researchers found.

Micrograph of Escherichia coli

Small molecule vaccine protects against UTI in miceSubscription

A vaccine using siderophores reduced bacterial burden in the urine and kidneys of mice, researchers report.

X-ray of arthritic hands

DMARDs do not increase post-surgical infection riskSubscription

Rates of post-surgical infections did not increase for patients taking disease-modifying anti-rheumatic drugs and biologics, researchers discover.

Coloured X-ray of the fingers of a patient with gout

Gout treatment does not raise CKD riskSubscription

Study shows serum urate levels can be lowered using allopuruinol in gout without risk to kidneys.

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