Acute side effects are common in studies of patients who have received ketamine for depression and more research is needed into long-term outcomes, researchers find.
Researchers argue that alternative dosing strategies for obese patients, in particular children, should be rigorously trialled.
Patients treated with prednisolone are likely to benefit from receiving the osteoporosis treatment alendronate, but further research is needed.
Researchers find that idarucizumab effectively counteracts the workings of anticoagulant dabigatran in emergency situations.
Researchers found that exposure to the antibiotic cefoperazone resulted in gut microbial imbalances in the mother that were transmitted to their offspring.
PPI use not linked to cognitive functionSubscription
A study conducted over a 14-year period found no convincing association between proton-pump inhibitor use and cognition.
IGF1R inhibitors could treat osteosarcomaSubscription
Over the last three decades there has been limited improvement in the prognosis of osteosarcoma, a primary malignancy of bone which is incurable in 40% of cases.
Researchers compared remission rates in patients with major depressive disorder who were either switched to another antidepressant or had their existing treatment augmented with an antipsychotic.
Researchers assess the use of antibiotics in combination with incision and drainage for the treatment of skin abscesses in comparison with drainage alone.
Study in The British Journal of Nutrition finds a link between vitamin D deficiency during pregnancy and delays in neurocognitive development in the first 42 months of a child’s life.
Careful consideration of the use of fluoxetine by pregnant women has been suggested by a recent meta-analysis study published in the British Journal of Clinical Pharmacology.
A meta-analysis reveals a significant association between the use of Viagra and low-stage melanoma but the criteria for causation were not met.
A large-scale study of malaria gene function reveals an abundance of essential parasite genes that could be targets for new antimalarial drugs.
Study reveals serotonin metabolism abnormalities as contributing factors to sudden infant death syndrome and suggests serotonin serum levels as a forensic biomarker.
High-dose vitamin D counteracts sunburn damageSubscription
A double-blinded, placebo-controlled interventional trial reveals high-dose vitamin D3 as a potent modulator of experimental sunburn induced by simulated solar radiation.
Molecular fingerprint could predict lung cancer patients who will respond to immunotherapySubscription
A study reveals that the transcriptional programme of tumour-infiltrating T cells in lung cancer might inform personalised immunotherapeutic treatment strategies.
A study in Scientific Reports reveals beta-blockers as potential modulators of cardiac gene expression.
A study in Nature contradicts a previous report on synaptic NMDAR inhibition by a ketamine metabolite, a potential antidepressant.
Prenatal paracetamol exposure alters brain and reproductive tract development in male miceSubscription
The need to limit the widespread exposure and use of paracetamol by pregnant women has been emphasised in a recent study published in the journal Reproduction.
Study reveals the importance of judicious antibiotic prescribing to reduce the harm that can result from antibiotic-associated adverse drug events.