Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Adverse drug reactions

Antidepressants associated with increased head injury risk in Alzheimer’s patients

Antidepressants might put Alzheimer’s patients at a higher risk of traumatic brain injuries, as well as falls.

Antidepressants are associated with an increased risk of falls and fractures in older people, but it is unknown whether they are associated with head injuries.

To explore this, researchers used data from a Finnish study of community-dwelling people with Alzheimer’s disease to compare 10,910 new antidepressant users with 21,820 matched non-users.

At median follow-up of 249 days, antidepressant use was associated with a 35% increased hazard of head injury (propensity score adjusted hazard ratio (HR) 1.35, 95% confidence interval [CI] 1.20–1.52) and 26% increased hazard of traumatic brain injury compared with non-use (HR 1.26, 95% CI 1.06–1.50). The risk was highest during the first 30 days of use and, for head injuries, remained elevated for more than two years of use.

Reporting in Alzheimer’s Research & Therapy (online, 1 August 2017), the team said that further research was needed to explore the link between antidepressants and head injuries, but that prescribers should carefully consider their appropriateness in vulnerable patients[1].

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203473

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Patient Care in Community Practice

    Patient Care in Community Practice

    Patient Care in Community Practice is a unique, practical guide for healthcare professionals or carers. Covers a range of non-medicinal products suitable for use at home.

    £21.00Buy now
  • Chronotherapeutics


    Chronotherapeutics discusses the pharmaceutical and therapeutic implications associated with biological clocks in humans.

    £37.00Buy now
  • Drugs in Use

    Drugs in Use

    Optimise drug therapy for your patients. These case studies help you bridge the gap between theoretical medicines knowledge and practical applications.

    £42.00Buy now
  • Application and Review of Pediatric Pharmacotherapy

    Application and Review of Pediatric Pharmacotherapy

    Increase your understanding of pharmacotherapy prescribed to pediatric patients with these realistic case studies.

    £32.00Buy now
  • Integrated Pharmacy Case Studies

    Integrated Pharmacy Case Studies

    Over 90 case studies based on real life patient-care scenarios. Each case includes learning outcomes and references.

    £42.00Buy now
  • Drugs and the Liver

    Drugs and the Liver

    Drugs and the Liver assists practitioners in making pragmatic choices for their patients. It enables you to assess liver function and covers the principles of drug use in liver disease.

    £37.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • old man head injury hospital bed ss 17

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.