Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Depression

Antimuscarinics increase risk of depression in women with overactive bladder

Researchers have found that patients with overactive bladder who are prescribed antimuscarinics have an increased subsequent risk of depressive disorder.

Coloured x-ray of a bladder

Source: Sovereign, ISM / Science Photo Library

A study has found that women who received an antimuscarinic for overactive bladder (pictured) were 38% more likely to be diagnosed with a depressive disorder than those who didn’t.

Research into the relationship between antimuscarinics for overactive bladder (OAB) and the subsequent risk of depression has provided conflicting results.

To explore, researchers from Taiwan conducted a retrospective study involving data on 1,952 women with OAB who received antimuscarinics who had been matched to 9,760 women with OAB who did not receive an antimuscarinic.

They found that, during the three-year follow-up period, women who received an antimuscarinic were subsequently 38% (95%CI, 1.15–1.64) more likely to be diagnosed with a depressive disorder than those who didn’t.

Reporting in the Journal of Clinical Pharmacology[1], the team says that further research is needed to identify a potential mechanism linking antimuscarinics to depressive disorder, but healthcare professionals should be alert to this relationship in order to help women seek prompt attention for depressive symptoms.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202689

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

RPS publications

Pharmaceutical Press is the publishing division of the Royal Pharmaceutical Society, and is a leading provider of authoritative pharmaceutical information used throughout the world.

Visit rpharms.com

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Coloured x-ray of a bladder

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.