Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

NSAIDs

Diclofenac and ibuprofen linked to significantly increased risk of cardiac arrest

Having studied data from nearly 30,000 patients with a history of cardiac arrest, researchers conclude that over-the-counter NSAIDs should only be available in pharmacies and at low doses and quantities.

Over the counter NSAIDS in Uk store

Source: Stephen Barnes / Alamy Stock Photo

Research published in the European Heart Journal: Cardiovascular Pharmacotherapy showed that diclofenac was linked to a 50% increased risk of cardiac arrest while ibuprofen was linked to a 31% increase in risk.

Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with increased cardiovascular risk for the past ten years, but the link between NSAIDs and cardiac arrest specifically has not been examined.

To investigate, researchers used the Danish Cardiac Arrest Registry to identify 28,947 patients who had had an out-of-hospital cardiac arrest between 2001 and 2010. The data showed that 3,376 were treated with an NSAID up to 30 days before their cardiac arrest.

The results, published in the European Heart Journal: Cardiovascular Pharmacotherapy[1] (2017;356:100-107), also showed that the NSAID diclofenac was linked to a 50% increased risk of cardiac arrest (odds ratio [OR] 1.50, 95% confidence interval [CI] 1.23­–1.82) while ibuprofen was linked to a 31% increase in risk (OR 1.31, 95% CI 1.14–1.51).

The researchers say that any conclusions on causality should be made with caution but recommend that over-the-counter NSAIDs should only be available at pharmacies, in limited quantities and at low doses.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202466

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Over the counter NSAIDS in UK store

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.