Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

NSAIDs

Diclofenac and ibuprofen linked to significantly increased risk of cardiac arrest

Having studied data from nearly 30,000 patients with a history of cardiac arrest, researchers conclude that over-the-counter NSAIDs should only be available in pharmacies and at low doses and quantities.

Over the counter NSAIDS in Uk store

Source: Stephen Barnes / Alamy Stock Photo

Research published in the European Heart Journal: Cardiovascular Pharmacotherapy showed that diclofenac was linked to a 50% increased risk of cardiac arrest while ibuprofen was linked to a 31% increase in risk.

Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with increased cardiovascular risk for the past ten years, but the link between NSAIDs and cardiac arrest specifically has not been examined.

To investigate, researchers used the Danish Cardiac Arrest Registry to identify 28,947 patients who had had an out-of-hospital cardiac arrest between 2001 and 2010. The data showed that 3,376 were treated with an NSAID up to 30 days before their cardiac arrest.

The results, published in the European Heart Journal: Cardiovascular Pharmacotherapy[1] (2017;356:100-107), also showed that the NSAID diclofenac was linked to a 50% increased risk of cardiac arrest (odds ratio [OR] 1.50, 95% confidence interval [CI] 1.23­–1.82) while ibuprofen was linked to a 31% increase in risk (OR 1.31, 95% CI 1.14–1.51).

The researchers say that any conclusions on causality should be made with caution but recommend that over-the-counter NSAIDs should only be available at pharmacies, in limited quantities and at low doses.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202466

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Integrated Pharmacy Case Studies

    Integrated Pharmacy Case Studies

    Over 90 case studies based on real life patient-care scenarios. Each case includes learning outcomes and references.

    £42.00Buy now
  • Making Medicines

    Making Medicines

    An illustrated history of therapeutics and pharmacy, from the Egyptians through to the present day.

    £26.00Buy now
  • Pharmacy Case Studies

    Pharmacy Case Studies

    Understand the application of therapeutics in clinical practice with Pharmacy Case Studies. This book helps you to demonstrate the knowledge gained during your studies.

    £32.00Buy now
  • Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions features over 400 closed book and calculation questions. With the registration exam having gone through a complete transformation in 2016, this volume has been developed around the new General Pharmaceutical Council (GPhC) guidelines.

    £32.00Buy now
  • Pharmacy Business Management

    Pharmacy Business Management

    Explains the financial, legal and marketing aspects of pharmacy business management. Case studies illustrate practical applications.

    £34.00Buy now
  • Lecture Notes in Pharmacy Practice

    Lecture Notes in Pharmacy Practice

    A comprehensive study guide which summarises the basic principles in pharmacy practice. Clear, bulleted information for quick reference.

    £42.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Over the counter NSAIDS in UK store

Jobs you might like

See more jobs

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.