Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Animal experimentation

Effects of ADHD drug on the brain are reversible, study suggests

Even high doses over an extended treatment period were not detectable in brain regions after a month’s abstinence, according to animal study.

Previous research has shown that behavioural changes in rats treated with methylphenidate (Ritalin), a commonly prescribed medication for attention-deficit hyperactivity disorder (ADHD), persist after treatment discontinuation.

In a study in the Journal of Neural Transmission[1] (online, 23 January 2017), the same researchers studied the effect of the drug on neurochemistry in adolescent rat brains.

They found that three months of a high-dose regimen of methylphenidate (30mg/kg MP for the first hour; 60mg/kg for the remaining 7 hours), increased dopamine-transporter and -receptor binding in multiple brain regions, some of which correlated with behavioural changes. However, when rats underwent a one-month abstinence period following methylphenidate exposure, these differences in dopamine binding were not observed.

The researchers say the findings suggest the effects of methylphenidate on dopamine neurochemistry are likely to be reversible. But, they say, it is still concerning given the role of these receptors in multiple psychiatric diseases and the increasingly common use of non-prescribed methylphenidate as a cognitive enhancer.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203092

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Sampson's Textbook of Radiopharmacy

    Sampson's Textbook of Radiopharmacy

    This well-established textbook provides specialised information on the use of radiopharmaceuticals in the detection and treatment of diseases.

    £79.00Buy now
  • Biological Therapeutics

    Biological Therapeutics

    An introduction to the treatment of disease using biological medicines derived from living plant and animal tissues.

    £32.00Buy now
  • Workplace Drug Testing

    Workplace Drug Testing

    Explains drug testing regulatory frameworks and all aspects of drug analysis. Case studies of successful programmes are included.

    £79.00Buy now
  • Drugs in Use

    Drugs in Use

    Optimise drug therapy for your patients. These case studies help you bridge the gap between theoretical medicines knowledge and practical applications.

    £42.00Buy now
  • Remington Education: Pharmaceutics

    Remington Education: Pharmaceutics

    Case studies and MCQs explaining the pharmaceutics behind drug delivery.

    £32.00Buy now
  • FASTtrack: Pharmacology

    FASTtrack: Pharmacology

    FASTtrack: Pharmacology is a study guide providing an account of drug action, as well as dealing with molecular pharmacology at a more advanced level.

    £24.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Fluorescence imaging of neurons in cortex of the brain

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.