Adverse drug reactions
Valbenazine shows efficacy for tardive dyskinesia in phase III trial
Promising results in the search for a drug to treat this involuntary movement disorder.
Tardive dyskinesia is a term used to describe involuntary movements of the face or body and can be a side effect of chronic exposure to antipsychotics.
In a phase III study, researchers compared the efficacy of a novel treatment for the condition, valbenazine, at two different doses (40 and 80 mg/day), to placebo, in 225 people with moderate or severe tardive dyskinesia.
Source: Ed / Wikipedia
After six weeks, dyskinesia, as measured by the Abnormal Involuntary Movement Scale, was virtually unchanged in the placebo group at a mean of -0.1 units. A significantly greater decrease was observed in the active treatment groups at a mean of -1.9 units in the 40mg/day group and -3.2 units in the 80mg/day group.
Reporting in the American Journal of Psychiatry (online, 21 March 2017), the team says the results indicate once-daily valbenazine could be an effective treatment for tardive dyskinesia. It was approved by the US Food and Drug Administration in April 2017.
Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202743
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