Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Vitamin E and selenium do not prevent dementia in older men

Older men taking the antioxidants for over a decade had the same rate of dementia as those taking placebo, researchers find.

Oxidative stress, an imbalance between the production of free radicals and the ability of the body to counteract their harmful effects, has been implicated as a key mechanism in dementia. Consequently, antioxidants have been of interest as a potential treatment for the condition.

A study, published in JAMA Neurology[1] (online, 20 March 2017), observed 7,540 older men for an average of 5.4 years and a subset of 3,786 men for up to 6.0 additional years. The men received either vitamin E or selenium alone, a combination of both, or a placebo.

The researchers found that the incidence of dementia (325 of 7,338 men; 4.4%) did not differ between the four study groups. They conclude that neither vitamin E nor selenium should be recommended as a preventive agent but identified the inclusion of only men and the relatively short supplement exposure time as key limitations of the study.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202489

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • MRI brain scan

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.