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Image 1 shows a normal spine and image 2 shows a spine affected by spondylitis

TNFα-inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritisSubscription

13 JAN 2017By , , , , , , , , ,

Abstract Spondyloarthropathy refers to a group of articular inflammatory diseases that share common genetic, clinical and radiological features in addition to their association with human leucocyte antigen (HLA)-B27 antigen. The aim of therapeutic management of patients with spondyloarthritis is to improve quality of life, control the symptoms of articular inflammation, prevent the structural damage of joints, and preserve the functional abilities, autonomy and social participation ...

Close up of a woman's hand holding hormone replacement therapy (HRT) pills

Establishing the risk related to hormone replacement therapy and cardiovascular disease in womenSubscription

10 JAN 2017By ,

Abstract Hormone replacement therapy (HRT) has a profound impact on the cardiovascular system in postmenopausal women, achieved through its effects on metabolic risk factors for coronary heart disease (CHD) and on arterial function. Observational studies have consistently shown an association between postmenopausal HRT use and a reduced incidence of CHD. However, the largest randomised trial initially reported no overall benefit on CHD risk. Subsequent analyses ...

All Review article

NHS pharmacist discusses patient care with a nurse on a ward

Examining the emerging roles for pharmacists as part of the urgent, acute and emergency care workforceSubscription

7 FEB 2017By , , , ,

Abstract In the future urgent, acute and emergency medicine clinical workforce, new models of care and care delivery need to be developed, in order to maintain and enhance standards of safe and accessible patient care. A departure from traditional (doctor-led) approaches to workforce planning, and an understanding of scope and governance surrounding emerging clinical roles is necessary to develop a sustainable, multi-skilled workforce across primary, community and secondary ...

Scanning electron micrograph (SEM) of a lymphocyte with HIV cluster

Pre-exposure prophylaxis should be a key component of a comprehensive HIV prevention package fully funded on the NHSSubscription

29 NOV 2016By

Abstract Pre-exposure prophylaxis (PrEP) is the medication taken by HIV-negative individuals to reduce their risk of contracting HIV infection. The large evidence base for the use of PrEP has been reviewed and recommended by the World Health Organization (WHO), a specialised agency of the United Nations that is concerned with international public health, the Joint United Nations Programme on HIV and AIDS (UNAIDS) and the National Institute for Health and Care ...

All Perspective article

Molecular model of C-reactive protein

Evaluating a point-of-care C-reactive protein test to support antibiotic prescribing decisions in a general practiceSubscription

By , , ,

Abstract Background: C-reactive protein (CRP) is a marker of infection and inflammation. It is high in bacterial infections but very low or close to zero in viral infections. The National Institute for Health and Care Excellence (NICE), England and Wales’s health technology assessment body, has issued guidance on pneumonia in adults; it recommends point-of-care (POC) CRP analysers when clinical assessment is inconclusive. If the CRP level ...

Oral anticoagulant therapy and INR blood test monitor

Assessing the impact of a targeted pharmacist-led anticoagulant review clinicSubscription

By , , ,

Abstract Background: Local guidance, supported by the 2014 National Institute for Health and Care Excellence (NICE) guideline CG180 for atrial fibrillation (AF), recommends that patients receiving inadequate anticoagulation with a vitamin K antagonist (VKA), including time in therapeutic range (TTR) of <65%, should be reassessed. These patients were identified by the anticoagulation monitoring service (AMS) and highlighted to GPs for review. ...

Close-up of a person taking a dry-blood spot test

Integrating community pharmacy testing for hepatitis C with specialist careSubscription

By Ryan Buchanan, Pembe Hassan-Hicks, Kevin Noble, Leonie Grellier, Julie Parkes, Salim I Khakoo

Abstract Background:  Many patients with hepatitis C virus (HCV) infection lie undiagnosed and a significant proportion of patients that have been identified are disengaged from specialist services. The Isle of Wight (IOW) typifies this issue, with an estimated 200 undiagnosed patients with HCV infection and a small number of known cases engaged with specialist services. Aim:  To reduce the burden of undiagnosed HCV ...

Elderly man consults with a carer about his medicines

Pharmacy at home: service for frail older patients demonstrates medicines risk reduction and admission avoidanceSubscription

By , , ,

The Exeter Cluster Pharmacy (ECP) team is part of an integrated community health and social care service, providing domiciliary medicines optimisation to around 145,000 people. The service undertakes clinical medication reviews for frail older people at home, assessing their risk of medicine-related harm in order to reduce these risks and potentially prevent hospital admissions.  Objective: An evaluation was completed in 2014 to assess the level of service ...

How useful are medicines helplines for patients discharged from hospital?Subscription

By , , Szn-Fang Li

This paper suggests that patient helplines support medicines optimisation by ensuring patients have easy access to pharmacy experts to discuss concerns about their medicines and improve the quality of their pharmaceutical care.

The package user test: a method for improving medicines packaging Subscription

By ,

This paper describes a new performance-based package user test that has the potential to improve drug package design and therefore reduce drug selection errors

We are all part virus — the role of human endogenous retrovirusesSubscription

By ,

Viruses lurk in our genome and science is only now starting to understand the important role that they might play in health and disease. Kalliopi Dodou and Paul Whiteley explain

Student reading in a library (Wavebreakmedia/Dreamstime.com)

Integrated examinations: supporting students with team-based learningSubscription

By , , ,

Jason Hall and colleagues explain how Manchester Pharmacy School is applying team-based learning to the MPharm course to integrate science and practice modules

A review of Controlled Drug incidents reported to the NRLS over seven yearsSubscription

To describe the number and types of patient safety incidents involving Controlled Drugs reported to the National Reporting and Learning System (NRLS) and the role of Accountable Officers for CDs (AOs) in incident reporting and learning.

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