Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Antiviral agents

No significant efficacy difference between courses of remdesivir in patients with severe COVID-19

A trial involving around 400 patients with severe COVID-19 has shown that there is little difference in clinical status after taking different courses of remdesivir.

Open access article

The Royal Pharmaceutical Society has made this article free to access in order to help healthcare professionals stay informed about an issue of national importance.

To learn more about coronavirus, please visit:

Remdesivir bottles


The researchers noted that the study was not a test of the efficacy of remdesivir in treating COVID-19, owing to the lack of a placebo

There is no significant difference in efficacy between five-day and ten-day courses of the antiviral remdesivir for patients with severe COVID-19 not requiring ventilation, research published in The New England Journal of Medicine has shown (27 May 2020)[1].

In an open-label, multicentre, phase III trial, 200 patients were randomised to receive treatment for five days and 197 were randomised to receive treatment for ten days. At baseline, those assigned to the ten-day group had a significantly worse clinical status than the other group.

By day 14, a clinical improvement of 2 points or more on a 7-point ordinal scale was observed in 64% of the five-day patients and 54% of the ten-day patients. After adjusting for the baseline clinical status, the researchers concluded that patients in both groups had a similar distribution in clinical status.

Owing to the lack of a placebo, the researchers pointed out that the study was not a test of the efficacy of remdesivir in treating COVID-19. However, they said that the results suggested that, if remdesivir was an active agent, supplies that are likely to be limited could be conserved with shorter durations of therapy.

“Patients who progress to mechanical ventilation may benefit from ten days of remdesivir treatment; further evaluation of this subgroup and of other high-risk groups … is needed to determine the shortest effective duration of therapy,” they added.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2020.20208021

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.