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Antibiotic resistance: A fragile defence

Last defence dam in antimicrobial resistance

Around 25,000 people die in the European Union each year from infections resistant to antibiotics. Third-generation cephalosporins are often useless against common bacteria like Escherichia coli, and fluoroquinolones are no longer the treatment of choice for gonorrhoea because resistance has become widespread. Here, you can find news stories and articles about the issue.

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Chief medical officer warns antibiotic resistance could signal 'end of modern medicine'

England’s chief medical officer Sally Davies has warned that if antibiotics lose their effectiveness it would spell “the end of modern medicine”.

Petri dish with E. coli culture, antimicrobial resistance

Wellcome Trust launches global project to map antibiotic resistance

A global project to help track and document diseases associated with antimicrobial resistance (AMR) has been launched, according to UK health charity the Wellcome Trust.

Urine in test tube

New test determines antibiotic susceptibility in less than 30 minutesSubscription

A diagnostic test for urinary tract infections, that affect 100 million women annually, could be valuable in the fight against antimicrobial resistance.

Wash your hands to help save antibiotics Subscription

29 September 2017: As part of the Royal Pharmaceutical Society (RPS) campaign on antibiotic resistance, Ash Soni, president of the RPS, and others hit the airwaves to explain how effective handwashing can help prevent infections. More than 20 TV and radio interviews took place, including on BBC Breakfast where Soni demonstrated the best technique for handwashing and pointed out that “it only takes 20 seconds to wash your hands properly, but if you get an infection you could ...

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Research on antimicrobial resistance

AMR and diagnostics: pointing the way to better infection controlSubscription

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Antimicrobial resistance — the ability of previously sensitive microorganisms to resist the effects of an antimicrobial agent — is a growing problem. The World Health Organization has warned that we could be moving into a post-antibiotic era where even minor injuries could lead to life-threatening infections, consequently putting an end to complex surgery and returning us to an era where childbirth is high-risk.

Scanning electron micrograph (SEM) of tuberculosis (TB) bacteria infecting macrophages

Fluoroquinolones for treating tuberculosisSubscription

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Tuberculosis (TB) remains a significant global health and socioeconomic challenge. The duration of current anti-TB therapies, the adverse effects of certain anti-TB drugs and the growing problem of drug-resistant TB on an international scale mean that it is imperative for new, effective and safe treatment regimens to be developed. Fluoroquinolones are a class of drugs that have been used in the treatment of TB for several decades. This article provides an overview of the current treatment ...

Micrograph of Clostridium difficile bacteria

Clostridium difficile: diagnosis and treatment update

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There are around 12,000 cases of Clostridium difficile infection (CDI) each year in the UK and during 1999 to 2007, deaths from CDI peaked at around 4,000 per year. This article summarises diagnosis and management, as well as the current therapeutic options for CDI, including faecal microbiota transplant.

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Destruction of a virus

Putting the rise of STIs in England into contextSubscription

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Laura Waters explains the rise of STIs in the UK, the possible reasons behind it and possible solutions, and considers the challenges posed by the current economic climate.

Alarm clock against a red background

AMR: time is running out, we need action nowSubscription

AMR is one of the biggest threats to modern medicine and the global economy, yet millions of people are unaware of its potentially catastrophic implications.

Man on chair measures tangled mess

Science reproducibility crisis: better measurement is required to tackle global health challengesSubscription

Measurement underpins UK trade and regulation, and helps us support innovation and government policy.

Scanning electron micrograph of methicillin-resistant Staphylococcus aureus (MRSA) bacteria

Antimicrobial therapies for Gram-positive infectionsSubscription

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Gram-positive bacteria are among the most common human pathogens associated with clinical infections, which range from mild skin infections to sepsis. In an era defined by antimicrobial resistance (AMR) and an increasing drive toward delivering patient care via ambulatory pathways, the paradigm for the management of infections is changing. Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), the best known cases of ...

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