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Antibiotic resistance: A fragile defence

Last defence dam in antimicrobial resistance

Around 25,000 people die in the European Union each year from infections resistant to antibiotics. Third-generation cephalosporins are often useless against common bacteria like Escherichia coli, and fluoroquinolones are no longer the treatment of choice for gonorrhoea because resistance has become widespread. Here, you can find news stories and articles about the issue.

MRSA culture in a petri dish

Non-medical prescribers are a key group in antimicrobial stewardship effortsSubscription

A rise in non-medical prescribers warrants their involvement in antimicrobial stewardship efforts, researchers conclude.

Drug-resistant E Coli

Triple-drug cocktail could conquer E coli 'superbug'

A strain of Escherichia coli with immunity to last-resort antibiotics can be destroyed with a novel combination of three existing drugs, according to researchers at the University at Buffalo, New York.

Drug-resistant N Gonorrhoeae

New antibiotic shown to be effective against gonorrhoea superbug

A new class of antibiotic has been found to be effective against Neisseria gonorrhoeae according to researchers from Imperial College London and the London School of Hygiene and Tropical Medicine.

Bacterial culture in petri dish study in laboratory

Global standard needed for antibiotic stewardship to halt resistance, say experts

Experts writing in Clinical Microbiology and Infection say there is a need for a global standard in terms of funding and core stewardship activities to combat antibiotic-resistant bacteria

More on antimicrobial resistance

Scanning electron micrograph (SEM) of tuberculosis (TB) bacteria infecting macrophages

Fluoroquinolones for treating tuberculosisSubscription

By , ,

Tuberculosis (TB) remains a significant global health and socioeconomic challenge. The duration of current anti-TB therapies, the adverse effects of certain anti-TB drugs and the growing problem of drug-resistant TB on an international scale mean that it is imperative for new, effective and safe treatment regimens to be developed. Fluoroquinolones are a class of drugs that have been used in the treatment of TB for several decades. This article provides an overview of the current treatment ...

Micrograph of Clostridium difficile bacteria

Clostridium difficile: diagnosis and treatment update

By , Christopher Eades, Luke SP Moore,

There are around 12,000 cases of Clostridium difficile infection (CDI) each year in the UK and during 1999 to 2007, deaths from CDI peaked at around 4,000 per year. This article summarises diagnosis and management, as well as the current therapeutic options for CDI, including faecal microbiota transplant.

Collage showing MRSA, research and antibiotics

New approaches to overcoming antimicrobial resistanceSubscription

By

As antibiotic resistance continues to threaten the treatment of various infections, researchers are looking for new ways to supplement and in some cases replace failing antimicrobial drugs.

More on antimicrobial resistance

Streak test on petri dish to test for antimicrobial resistance

Pharmacist independent prescribers can make a significant contribution to antimicrobial stewardshipSubscription

By Karen Hodson, Rhian Deslandes, Molly Courtenay

Karen Hodson, member of the Welsh Pharmacy Board, and colleagues discuss their experiences of how pharmacist prescribers can help in antimicrobial stewardship.

Micrograph of Acinetobacter baumannii bacteria

Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitorSubscription

By , ,

Over the past decade, infections caused by multidrug-resistant Gram-negative organisms have increased. The limited availability in treatment options for these infections prompted both the UK to create a five-year antimicrobial resistance strategic plan to stimulate the development of new antibiotics, and the Infectious Diseases Society of America to call for ten new antimicrobial agents to be developed by 2020. Ceftazidime-avibactam is a combination of a third-generation ...

Illustration showing alarm due to rise of antimicrobial resistant bacteria from biocides and heavy metals

How chemicals and heavy metals contribute to antimicrobial resistanceSubscription

By

Evidence is emerging that biocides and heavy metals all contribute to the growing problem of antimicrobial resistance.

Balancing action on antimicrobial resistance with animal welfareSubscription

By ,

As almost everyone in the business of caring for the health of humans and animals is acutely aware, on our current trajectory, it is estimated that antimicrobial resistance (AMR) will cause 10 million deaths annually by 2050, with many arising from simple infections following routine operations. This is why the UK government has placed antimicrobial resistance at the top of its risk register alongside terrorism and pandemic influenza.

More on antimicrobial resistance

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